Measuring ovarian function in young cancer survivors.

摘要: It is known that young female cancer survivors are at higher risk for decreased fertility and early menopause. Because the of these outcomes varies by age, type, treatment regimen other patient-specific characteristics, there a need valid tools measuring predicting reproductive function in this population. Ovarian reserve tests (ORT) include serum ultrasound biomarkers used characterizing healthy ovarian aging prior to treatment. This review summarizes efforts translate ORT use patients. To date, small longitudinal cross-sectional studies patients demonstrate gonadotoxic chemotherapy impact ORT. While follicle stimulating hormone (FSH), anti-Mullerian (AMH), inhibin B, antral count (AFC) volume have all been demonstrated change with exposure therapy, FSH, AMH AFC appear be most sensitive. More data needed determine long-term effect hormonal agents from tamoxifen GnRH agonists on The unilateral oophorectomy acutely or not known. There some postulating itself may impair reserve. Among survivors, correlate amenorrhea. Even normal menstrual cycles, measures suggest underlying than age-matched women. optimal time test large number combined estrogen progesterone contraceptives. A significant utility would able predict no outcome date. goal future girls women their as surrogate predictors infertility failure. do so, large-scale collected through cooperative group mechanisms. Epidemiologically, move association develop into appropriate screening predictive tests.