Rodent models of human amyloidoses
作者： Alan D. Snow
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摘要: In vivo assays for selecting candidate therapeutics inhibiting amyloidoses, such as congophilic and fibrillar β/A4 amyloid deposition in brain. A reagent is administered to a first rat infusate comprising peptide perlecan by continuous infusion at least one week into hippocampus. The selected therapeutic brain if the diminishes congo red thioflavin S staining indicative of adjacent site, compared with second receiving consisting essentially perlecan.
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