Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)

摘要: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, compositions thereof. Also provided are methods kits involving the inventive or for treating preventing proliferative diseases (e.g., cancers leukemia, lymphoma, melanoma, multiple myeloma, breast cancer, Ewing' s sarcoma, osteosarcoma, brain neuroblastoma, lung cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory autoimmune diseases) in a subject. Treatment subject with disease using compound composition may inhibit aberrant activity kinase, such as cyclin-dependent kinase (CDK) 7 (CDK7), 12 (CDK12), 13 (CDK13)), therefore, induce cellular apoptosis and/or transcription