Molecular targeted therapy in epithelial ovarian cancer

摘要: Ovarian cancer is the most common cause of mortality tumors from gynecologic origin and often diagnosed after patients have already progressed to advanced disease stage. The current standard care for treatment epithelial ovarian includes cytoreductive surgery followed by adjuvant chemotherapy. However, development resistance, recurrence poor prognosis still important problems. Despite enhancements in tumor debulking combination regimens, majority not only experience adverse effects, but also eventually relapses. Therefore, additional therapeutic possibilities need be explored minimize events prolong progression-free survival overall response rates patients. Recent advances understanding molecular mechanisms genetics led identification new targets. In this review we focus on clinical efficacy targeted therapy cancer.