Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer. I. Correlation of receptor expression with prognostic factors in patients with ovarian cancer.
作者： Andrew Berchuck , Gustavo C. Rodriguez , Ahmed Kamel , Richard K. Dodge , John T. Soper
DOI: 10.1016/S0002-9378(11)80044-X
关键词:
摘要: Previous studies in breast and bladder cancer have suggested that epidermal growth factor receptor is expressed by only a proportion of cancers associated with poor clinical outcome. We used monoclonal antibody specifically reactive the extracellular domain to localize this immunohistochemically frozen sections normal ovary epithelial ovarian cancer. Normal epithelium was found express all cases. Among 87 cancers, however, 23% did not detectable receptor. Epidermal expression related histologic grade or stage, but survival ( p
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