Soluble Epidermal Growth Factor Receptor: A Biomarker of Epithelial Ovarian Cancer
作者： Andre T. Baron , Jacqueline M. Lafky , Cecelia H. Boardman , Elsa M. Cora , Marites C. Buenafe
DOI: 10.1007/978-0-387-98094-2_9
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摘要: The epidermal growth factor receptor (EGFR) is the prototypic member of ErbB tyrosine kinase family, which includes ErbB1 (EGFR), ErbB2 (HER2, Neu), ErbB3 (HER3), and ErbB4 (HER4).1, 2, 3 Biochemical structural studies show that mature form EGFR a 170-kDa plasma membrane protein composed extracellular, transmembrane-spanning, intracellular domains.4The extracellular domain divided into four subdomains: subdomains I III function in binding, II IV confer secondary tertiary structure to through cysteine residues. also subdomain carboxy-terminal regulatory several autophosphorylation sites. In general, binding results dimerization with...
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