Epidermal growth factor receptor and podocin predict nephropathy progression in type 2 diabetic patients through interaction with the autophagy influencer ULK-1
作者： Aya Aly A. El-Shazly , Alaliaa M. Sallam , Mohamed H. El-Hefnawy , Hala O. El-Mesallamy
DOI: 10.1016/J.JDIACOMP.2018.11.007
关键词:
摘要: Abstract Aims Diabetic nephropathy (DN) that progress to end stage renal failure is a serious health problem. Autophagy involved in DN pathogenesis. Finding prognostic biomarkers can help the future status prevision. Therefore, aim of current study was evaluate and correlate circulating levels autophagy regulator protein Unc-51-like kinase 1 (ULK-1) with widely expressed receptor mammalian kidney; epidermal growth factor (EGFR); key functional podocyte podocin (PDCN). Methods Serum were assessed by ELISA 72 type 2 diabetic patients classified according their urinary albumin/creatinine ratio; 19 normoalbuminuric, 37 microalbuminuric 16 macroalbuminuric patients; age sex matched 18 healthy controls. Results Microalbuminuria macroalbuminuria exhibited decreased ULK-1, EGFR PDCN levels. Only showed lower normoalbuminuria compared ULK-1 significantly higher microalbuminuria patients. correlated each other some metabolic parameters. Conclusions predict early impairment while highlight progressive risk may interact synergistically dysregulation as pathogenic mechanism induction progression.
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