Biologically oriented organic sulfur chemistry. 14. Antiinflammatory properties of some aryl sulfides, sulfoxides, and sulfones.

摘要: To extend earlier work, to examine the possibility that certain sulfoxides might serve as counterparts of amines in receptor-site interactions, and add little information available about medicinal chemistry, were prepared general structure XArS(O)C6H4(CHR)nCO2H, together with sulfides some sulfones. The products evaluated antiinflammatory agents by carrageenan-edema inhibition uv-erythema inhibition. Four compounds had activity roughly comparable aspirin or phenylbutazone one other these assays (2a-c, 3b). Sulfoxides did not seem especially promising a class usually less active than corresponding sulfides. two most interesting assays, o-(phenylthio)phenylacetic acid (2b) its sulfoxide 3b, no significant adjuvant arthritis. Hydrogen-bonding effects are indicated acids their absence esters.