Improving Fluorouracil Chemotherapy with Novel Orally Administered Fluoropyrimidines

摘要: During the 40 years since initial synthesis of fluorouracil, there have been many attempts to improve fluoropyrimidine chemotherapy. These included utilisation different schedules fluorouracil administration, modulation metabolism with other drugs increase its therapeutic benefit, and prodrugs that are potentially more effective less toxic. Of particular interest at present is clinical evaluation several new can be orally administered. include capecitabine, tegafur/uracil (UFT®), eniluracil (GW-776C85; 5-ethynyluracil), S-1, emitefur (BOF-A2). The pharmacological principles influenced development these initially presented. This followed by a review our current knowledge pharmacology each agents, focusing on antitumour activity toxicity from studies conducted in US. Studies tegafur/uracil, early indicate least similar protracted infusion but additional quality-of-life economic benefits.