The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress.

摘要: The nonpeptide CRH antagonist antalarmin has been shown to block both behavioral and endocrine responses CRH. However, it's potential activity in blunting sequelae of stressor exposure not assessed. Because antagonism central by alpha-helical attenuates conditioned fear responses, we sought test this regard. In addition, it remains unclear as whether is a result receptor blockade during conditioning or testing. Thus, explored mediates the induction expression (freezing context previously associated with 2 footshocks; 1.0 mA, 5 sec each). Furthermore, because rats exposed inescapable shock (IS; 100 shocks, 1.6 each), demonstrate enhanced conditioning, investigated effect would be blocked antalarmin. Antalarmin (20 mg/kg x ml i.p.) impaired fear. enhancement produced prior IS. Despite marked effects observed antalarmin-treated rats, had no on IS-induced rises ACTH corticosterone. did response footshocks.