摘要: Human B cell stimulatory factor 2 (originally designated BSF2) was initially characterized and isolated as a T cell-derived that caused the terminal maturation of activated cells to immunoglobulin producing cells. Molecular cloning cDNA has revealed BSF2 is identical with 26 kD protein, interferon β2, plasmacytoma growth hepatocyte stimulating designation “IL-6” been proposed for this molecule. It now known BSF2/IL-6 wide variety biological functions abnormal regulation expression may be related pathogenesis certain autoimmune diseases such rheumatoid arthritis multiple myeloma.
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