ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer

作者: Roxsan Manshouri , Etienne Coyaud , Samrat T. Kundu , David H. Peng , Sabrina A. Stratton

DOI: 10.1038/S41467-019-12832-Z

关键词:

摘要: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, due in part to propensity metastasize. Aberrant epithelial-to-mesenchymal transition (EMT) a proposed model for initiation metastasis. During EMT cell-cell adhesion reduced allowing cells dissociate and invade. Of EMT-associated transcription factors, ZEB1 uniquely promotes NSCLC disease progression. Here we apply two independent screens, BioID an Epigenome shRNA dropout screen, define interactors that are critical metastatic NSCLC. We identify NuRD complex as co-repressor Rab22 GTPase-activating protein TBC1D2b ZEB1/NuRD target. find suppresses E-cadherin internalization, thus hindering invasion

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