作者: K. Kuroi , C. Tanaka , M. Toi
DOI: 10.3892/IJO.19.1.143
关键词:
摘要: The nucleosome is the primary repeating unit of DNA organization in chromatin, and cell death may lead to increased levels circulating nucleosomes plasma (PNLs) various circumstances such as inflammation, pulmonary embolism, autoimmune disease, cancer. Cell can also be induced by chemotherapeutic agents. We investigated PNLs 99 patients with breast cancer, 26 recurrent 11 benign 27 other histological types In 18 cancer who received docetaxel (D, 60 mg/m2) every 3 weeks second line therapy after an anthracycline-based regimen, were before during administration D. One hundred seventy-four healthy controls (111 females, 63 males) without any evidence disease investigated. detected using detection ELISAplus kit. significantly higher (mean +/- SD: 0.135 0.213) (0.182 0.196) compared female (0.010 0.012) (p < 0.01). no correlation was found between clinicopathological characteristics. On hand, decreased mastectomy 0.05). Patients (0.244+/-0.383) showed 0.01), elevated independently type a transient increase 24 h D, these increases correlated degree subsequent leukopenia. follow-up study, pretreatment baseline markedly when response obtained, whereas there decrease either stable or progressive disease. Thus, patients, seem sensitive marker that could predictive both leukopenia chemotherapy.