Molecular drug targets and therapies for Alzheimer’s disease

摘要: Alzheimer’s disease (AD) is a neurodegenerative disorder that characterized by normal memory loss and cognitive impairment in humans. Many drug targets disease-modulating therapies are available for treatment of AD, but none these effective enough reducing problems associated with recognition memory. Potential so far reported AD β-secretase, Γ-secretase, amyloid beta (Aβ) Aβ fibrils, glycogen synthase kinase-3 (GSK-3), acyl-coenzyme A: cholesterol acyl-transferase (ACAT) acetylcholinesterase (AChE). Herbal remedies (antioxidants) natural metal-chelators have shown very significant role the risk as well lowering effect patients. Researchers working direction antisense stem cell-based cure which mainly depends on clearance misfolded protein deposits — including Aβ, tau, alpha-synuclein. Computational approaches inhibitor designing, interaction analysis, principal descriptors an absorption, distribution, metabolism, excretion toxicity (ADMET) study could speed up process development higher efficacy less chance failure. This paper reviews known drugs, targets, existing future AD.