Distribution of Paroxetine in Postmortem Fluids and Tissues

摘要: Paroxetine is a selective serotonin reuptake inhibitor that commonly prescribed drug for the treatment of depression, obsessive-compulsive disorder, panic social anxiety premenstrual dysphoric and post-traumatic stress disorder. There are certain side effects associated with paroxetine use could negatively affect pilot’s performance become factor in an aviation accident. Such include nausea, drowsiness, insomnia, dizziness. It has also been suggested may increase suicidal behavior ideation. When relying on postmortem specimens interpretive value, general understanding distribution throughout fluids tissues important. Utilizing n-butyl chloride liquid/liquid extraction followed by gas chromatograph/mass spectrometer (GC/MS) analysis selected ion monitoring, laboratory developed method identification, characterization, quantitation paroxetine. The linear dynamic range was determined to be 3.13 – 1600 ng/mL blood. then concentrations various obtained from nine fatal accident cases. typical specimen types analyzed each case included blood, urine, vitreous humor, liver, lung, kidney, spleen, muscle, brain, heart, bile. Blood these cases ranged 0.019 0.865 µg/mL. paroxetine, expressed as mean specimen/blood ratio, was: 1.67 ± 1.16 urine (n=4), 0.08 0.04 humor (n=6), 5.77 1.37 liver (n=8), 9.66 2.58 lung (n=9), 1.44 0.57 kidney 3.80 0.69 spleen 0.15 muscle 4.27 2.64 brain (n=7), 1.05 0.43 heart (n=8). results this study show readily distributed body. large standard deviations coefficients suggest likely can experience significant concentration changes.