A systematic review of biomarkers in the diagnosis of infective endocarditis
作者： Magnus G. Snipsøyr , Maja Ludvigsen , Eskild Petersen , Henrik Wiggers , Bent Honoré
DOI: 10.1016/J.IJCARD.2015.09.028
关键词:
摘要: Timely diagnosis of bacterial infective endocarditis (IE) is crucial, as mortality remains high in this severe infection, currently without any distinct biological markers. Our goal was to evaluate potential diagnostic biomarkers by reviewing current literature. The MEDLINE, Embase and Scopus databases were searched for articles published from 1980 through June 2015 restricted English, Norwegian, Danish Swedish. Eighteen studies qualified, providing a review the most promising candidates future studies. Several are inconclusive, since they characterized using improper control groups. Patients with IE have bacteremia, groups should therefore be patients bacteremia IE. Based on research, N-terminal-pro-B-type natriuretic peptide (NT-proBNP) alone or combination Cystatin C (Cys C), lipopolysaccharide-binding protein (LBP), troponins, aquaporin-9 (AQP9), S100 calcium binding A11 (S100A11), E-selectin (CD62E) VCAM-1 (CD54) interleukin-6 (IL-6)
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