Oral ketoconazole and amphotericin B for the prevention of yeast colonization in patients with acute leukaemia

摘要: Forty-eight neutropenic patients with acute leukaemia were randomly allocated to receive, as antifungal prophylaxis, either ketoconazole, 400 mg once daily (K), or amphotericin B tablets and lozenges (A), both ketoconazole together (K + A). Antifungal prophylaxis was considered have failed if (1) there evidence of increasing colonization the oropharynx faeces Candida spp. other yeasts, (2) systemic therapy begun empirically. Prophylaxis in nine 17 given K, four 19 A, 12 K A. The differences between three regimens not statistically significant, neither any significant difference mean duration neutropenia before failed. absorption impaired when neutropenic. We conclude that more nor less effective than prevention yeast patients.