Exploring the Chiral Recognition of Carboxylates by C2-Symmetric Receptors Bearing Glucosamine Pendant Arms.
作者： Dawid Lichosyt , Sylwia Wasiłek , Janusz Jurczak
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摘要: Two urea-based receptors containing a glucosamine derivative were synthesized and investigated in terms of their ability to recognize chiral achiral anions. Both demonstrated high affinity toward carboxylates very competitive DMSO/water mixtures. The recognition properties these compounds studied using structurally differentiated guests derived from mandelic acid α-amino acids. We found that receptor 1 exhibits significantly higher enantioselectivities than compound 2 for all anions investigated, with KS/KR ratio up 2. This low enantiodiscrimination the case is attributed lack interactions between its sugar moieties side chain anions, due inadequate spatial arrangement.
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