Bioreactors for Tissue Engineering

摘要: A variety of bioreactor designs exist today as a result previous efforts by engineers and researchers to construct optimal systems for particular tissue engineering application. The primary purpose any is provide sterile cell culture environment that can be tightly controlled. simple petri dish complex an automatically controlled, cyclically loaded three-dimensional biochamber. number laboratories have designed custom bioreactors apply mechanical stimuli cells grown in monolayer or conditions. Varying levels complexity exist; typically, the incorporate at least one five common loading regimens, including perfusion fluid flow, hydrostatic pressure, uniaxial displacement, biaxial microgravity (Fig. 10.1) [10]. Bioreactors used vitro more similar vivo condition; dynamic are necessary appropriate, physiologically relevant [1].