Synthesis of Oxadiazolyl, Pyrazolyl and Thiazolyl Derivatives of Thiophene-2-Carboxamide as Antimicrobial and Anti-HCV Agents.
作者： Ola H Rizk , Omaima G Shaaban , Abeer E Abdel Wahab , None
DOI: 10.2174/1874104501711010038
关键词:
摘要: Introduction Three series of pyrazole, thiazole and 1,3,4-oxadiazole, derivatives were synthesized starting from 5-amino-4-(hydrazinocarbonyl)-3-methylthiophene-2-carboxamide (2). Methods All compounds investigated for their preliminary antimicrobial activity. They proved to exhibit remarkable activity against Pseudomonas aeruginosa with insignificant towards Gram positive bacterial strains fungi. Results In-vitro testing the new on hepatitis-C virus (HCV) replication in hepatocellular carcinoma cell line HepG2 infected utilizing reverse transcription polymerase chain reaction technique (RT-PCR) generally showed inhibition HCV RNA (-) strands at low concentration, while, eight compounds; 3a, 6, 7a, 7b, 9a, 9b, 10a 11b inhibit (+) very concentration range 0.08-0.36 μg/mL. Conclusion Compounds 7b displayed highest anti-HCV activities this study.
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