Renal sodium handling and sodium sensitivity.
作者： Alissa A. Frame , Richard D. Wainford
DOI: 10.23876/J.KRCP.2017.36.2.117
关键词:
摘要: The pathophysiology of hypertension, which affects over 1 billion individuals worldwide, involves the integration actions multiple organ systems, including kidney. kidney, governs sodium excretion via several mechanisms pressure natriuresis and renal transporters, is central to long term blood regulation salt sensitivity pressure. impact handling in health hypertension a critical public issue owing excess dietary consumed globally significant percentage global population exhibiting sensitivity. This review highlights recent advances that have provided new insight into pressure, with focus on genetic, inflammatory, dietary, sympathetic nervous system oxidative stress influence excretion. Increased understanding integrated regulate has potential identify novel therapeutic targets refine guidelines designed treat prevent hypertension.
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