Neuropeptides as signal molecules in common with leukocytes and the hypothalamic–pituitary–adrenal axis
作者： Eric M. Smith
DOI: 10.1016/J.BBI.2007.08.005
关键词:
摘要: There exists a bidirectional regulatory circuit between the nervous and immune systems. This regulation has been shown to be mediated in part through neuroendocrine hormones cytokines. Both systems have receptors for both types of signal molecules. The system cytokines it also synthesizes responds So, is not too far-fetched believe that peptide could bind leukocytes modulate functions. However, widely known functional, neuropeptide hormones. will discussed this paper citing plethora evidence. aim summarize evidence by using three neuropeptides are synthesized functions as examples; corticotropin (ACTH), endorphin (END), releasing factor (CRF). production action these explained. Finally, potential physiological role leukocyte-derived ACTH, END, CRF inflammation localized hypothalamic-pituitary-like axis discussed.
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