Memory self-appraisal in middle-aged and older adults with the apolipoprotein E-4 allele

摘要: OBJECTIVE: Because subjective memory complaints may indicate subtle functional brain abnormalities, the authors studied influence of major genetic risk for Alzheimer’s disease, apolipoprotein E-4 (APOE-4) allele, on self-reports performance in middle-aged and older adults. METHOD: Subjective objective assessments were compared relation to presence or absence APOE-4 allele 39 cognitively intact persons with mild complaints. RESULTS: Subjects had lower scores verbal measure retrospective functioning. Among subjects age range where has its greatest disease (55–74 years), group frequency forgetting. Moreover, standardized difference functioning between two groups increased when mid-age-range gro...