Stool Bacteriomic Profiling in Patients with Metastatic Renal Cell Carcinoma Receiving Vascular Endothelial Growth Factor–Tyrosine Kinase Inhibitors
作者： Sumanta K. Pal , Sierra M. Li , Xiwei Wu , Hanjun Qin , Marcin Kortylewski
DOI: 10.1158/1078-0432.CCR-15-0724
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摘要: Purpose: Diarrhea occurs in approximately half of patients with metastatic renal cell carcinoma (mRCC) receiving vascular endothelial growth factor-tyrosine kinase inhibitors (VEGF-TKIs). We evaluated the relationship between VEGF-TKI-related diarrhea and stool microbiota. Experimental Design: Stool samples were collected from 20 mRCC VEGF-TKIs. 16S rRNA sequencing was used to characterize bacteriomic profiling patients. Assay validation Salmonella typhimurium spike-in experiments suggested greatest speciation use V5 region. Results: Higher levels Bacteroides spp lower Prevotella found diarrhea. In addition, VEGF-TKIs appeared have less relative abundance Bifidobacterium as compared previous reports based on healthy subjects. Conclusions: thus demonstrated interplay microbiota VEGF-TKI induced Further studies are warranted evaluate potential causative role pre-existing dysbiosis related
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