Animal Models of Lung Disease

摘要: Animal models afford the opportunity for investigators to study mechanisms of human disorders by experimentally manipulating a number controlled variables. Experimental can be arbitrarily divided into (a) spontaneous disease models, which are mutant animals that carry similar condition; (b) obtained through genetic manipulation, in other words, gene-modified including: transgenic and knock out (c) chemically or physically induced changes. Researchers have chose from possibilities such as species strain animal, environment, genome investigate molecular interactions involved pathogenesis many diseases.1 also provide unique test potential therapeutic intervention. Well-developed animal should share features with specific disorders. Although basic biology terminology is covered chapters this book, it convenient briefly review technology development mice.