Amino acid sequence data on glial fibrillary acidic protein (GFA); implications for the subdivision of intermediate filaments into epithelial and non-epithelial members.

摘要: Determination of 50% the sequence astrocyte-specific intermediate filament (IF) protein documents hypervariable regions as well parts coiled-coil array glial fibrillary acidic (GFA). The results show that four non-epithelial IF proteins (myogenic desmin, mesenchymal vimentin, GFA and neurofilament 68 K protein) known to form homopolymers are much more closely related than epithelial keratins, which seem heteropolymers only. Of proteins, desmin vimentin most related, since has a shorter non-alpha-helical at amino terminus. We discuss possibility terminal arrays, because their length variability, responsible for differences distinct with respect physical-chemical properties such low ionic strength-induced depolymerization into protofilaments.