Estimation of the lipophilicity of anti-HIV nucleoside analogues by determination of the partition coefficient and retention time on a Lichrospher 60 RP-8 HPLC column.

作者: J. Balzarini , M. Cools , E. De Clercq

DOI: 10.1016/S0006-291X(89)80063-4

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摘要: Summary There is a close linear correlation between the log partition coefficient (P ) of series 2′-deoxyriboside (dR), 2′,3′-didehydro-2′,3′-dideoxyriboside (ddeR), 2′,3′-dideoxyriboside (ddR), 3′-fluoro-2′,3′-dideoxyriboside (FddR) and 3′-azido-2′,3′-dideoxyriboside (AzddR) derivatives uracil, cytosine, thymine, guanine, adenine 2,6-diaminopurine their retention times (R t on Lichrospher 60 RP-8 HPLC column (correlation r > 0.970). Within each class compounds following order increasing lipophilicity was noted : dR

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