Efficacy of Cicuta virosa medicinal preparations against pentylenetetrazole-induced seizures.

摘要: Epileptic seizures are characterized by imbalanced inhibition-excitation cycle that triggers biochemical alterations responsible for jeopardized neuronal integrity. Conventional antiepileptic drugs (AEDs) have been the mainstay option treatment and control; however, symptomatic control potential to exacerbate seizure condition calls viable alternative these chemical agents. In this context, natural product-based therapies accrued great interest in recent years due competent disease management lower associated adversities. Cicuta virosa (CV) is one such herbal remedy used traditional system of medicine against myriad disorders including epilepsy. Homeopathic medicinal preparations (HMPs) CV were assessed their efficacy pentylenetetrazole (PTZ)-induced acute kindling models HMPs increased latency reduced duration tonic-clonic phase model while lowering score signified role modulating GABAergic neurotransmission potassium conductance. Kindling-induced impairment cognition, memory, motor coordination was ameliorated substantiated imparting sustained fortification. Furthermore, evaluation showed attenuated oxidative stress load through lipid peroxidation strengthened free radical scavenging mechanism. Taken together, exhibited promising results must be further molecular epigenomic studies.