Regulation of neuronal nitric oxide synthase mRNA levels in rat brain by seizure activity

摘要: The regulation of neuronal nitric oxide synthase (NOS) mRNA levels during kindling epileptogenesis in the rat brain was investigated using situ hybridization. Following 40 rapidly recurring seizures evoked by hippocampal stimulations, NOS expression decreased 56% dentate granule cell layer (maximum at 2 h) and increased 420,105 1260% CA1 CA3 pyramidal layers piriform cortex, respectively 12-24 h). Gene had returned to control after one week. presumed alterations production, following changes shown here, may modulate synaptic function development, could influence vulnerability epileptic insults.