NADPH-diaphorase-stained neurons after experimental epilepsy in rats.
作者： E Talavera , G Martınez-Lorenzana , G Corkidi , M Léon-Olea , M Condes-Lara
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摘要: Abstract The aim of this study was to determine the neuronal participation nitric oxide (NO) in experimental epilepsy. To reach objective, we established amount cells presenting synthase (NOS) and amygdaline concentrations l -arginine–nitric synthesis pathway. A group fully epileptic rats, induced by kindling procedure that had reached at least 10 generalized seizures, studied. We evaluated behavioral stages, electroencephalographic activities, histochemical NOS-positive carried out high-pressure liquid chromatography (HPLC) determinations arginine, citrulline, glutamic acid. Our results showed electrographic frequency, duration were increased during process. Image processing system NOS two types intensities cell stains hippocampus, caudate-putamen, amygdala. When independently counted stain cells, a selective increase number density weak-stained observed, while dark-stained did not change studied structures. Additionally, acid amygdala kindled animals. differential specific stained expressing synthase, as well pathway amygdala, suggested relationship with progressive augmentation electrophysiological hyperactivity characteristic
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elsevier.com参考文章(50)
P. Michael Conn, Methods in neurosciences Methods in Neurosciences. ,vol. 10, ,(1991) , 10.1016/B978-0-12-185269-6.50005-9
E.C. Hirsch, O. Lejeune, G. Colliot, G. Corkidi, M. Tajani, Computer Methods in Nuclei Cartography Methods in Neurosciences. ,vol. 10, pp. 62- 79 ,(1992) , 10.1016/B978-0-12-185269-6.50010-2
JO McNamara, Cellular and molecular basis of epilepsy The Journal of Neuroscience. ,vol. 14, pp. 3413- 3425 ,(1994) , 10.1523/JNEUROSCI.14-06-03413.1994
T Herdegen, S Brecht, B Mayer, J Leah, W Kummer, R Bravo, M Zimmermann, Long-lasting expression of JUN and KROX transcription factors and nitric oxide synthase in intrinsic neurons of the rat brain following axotomy The Journal of Neuroscience. ,vol. 13, pp. 4130- 4145 ,(1993) , 10.1523/JNEUROSCI.13-10-04130.1993
Edmund Przegaliñski, Leokadia Baran, Joanna Siwanowicz, The role of nitric oxide in chemically- and electrically-induced seizures in mice. Neuroscience Letters. ,vol. 217, pp. 145- 148 ,(1996) , 10.1016/0304-3940(96)13085-8
S. T. Meller, G. F. Gebhart, Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain. ,vol. 52, pp. 127- 136 ,(1993) , 10.1016/0304-3959(93)90124-8
S. Kaura, H. F. Bradford, A. M. J. Young, M. J. Croucher, P. D. Hughes, Effect of amygdaloid kindling on the content and release of amino acids from the amygdaloid complex : in vivo and in vitro studies Journal of Neurochemistry. ,vol. 65, pp. 1240- 1249 ,(2002) , 10.1046/J.1471-4159.1995.65031240.X
V. Mollace, G. Bagetta, G. Nisticò, Evidence that L-arginine possesses proconvulsant effects mediated through nitric oxide. Neuroreport. ,vol. 2, pp. 269- 272 ,(1991) , 10.1097/00001756-199105000-00014
Barbara L. Trommer, Joseph F. Pasternak, NMDA receptor antagonists inhibit kindling epileptogenesis and seizure expression in developing rats. Developmental Brain Research. ,vol. 53, pp. 248- 252 ,(1990) , 10.1016/0165-3806(90)90014-P
M.V. Sofroniew, A.C. Cuello, J.B. Martin, N.W. Kowall, R.J. Ferrante, M.F. Beal, E.P. Richardson, Neuropeptide Y, somatostatin, and reduced nicotinamide adenine dinucleotide phosphate diaphorase in the human striatum: A combined immunocytochemical and enzyme histochemical study Neuroscience. ,vol. 20, pp. 817- 828 ,(1987) , 10.1016/0306-4522(87)90242-9