High‐Performance Nucleic Acid Sensors for Liquid Biopsy Applications
作者： Jagotamoy Das , Shana O. Kelley
关键词:
摘要: Circulating tumour nucleic acids (ctNAs) are released from tumours cells and can be detected in blood samples, providing a way to track tumors without requiring tissue sample. This "liquid biopsy" approach has the potential replace invasive, painful, costly biopsies cancer diagnosis management. However, very sensitive specific is required detect relatively low amounts of mutant sequences linked because they masked by high levels wild-type sequences. review discusses high-performance acid biosensors for ctNA analysis patient samples. We compare sequencing- amplification-based methods next-generation sensors ctDNA ctRNA (including microRNA) profiling, such as electrochemical methods, surface plasmon resonance, Raman spectroscopy, microfluidics dielectrophoresis-based assays. present an overview analytical sensitivity accuracy these well biological technical challenges present.
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