Uptake of Polymyxin B into Renal Cells
作者： Kamilia Abdelraouf , Kai-Tai Chang , Taijun Yin , Ming Hu , Vincent H. Tam
DOI: 10.1128/AAC.02557-14
关键词:
摘要: ABSTRACT Polymyxin B is increasingly used as a treatment of last resort against multidrug-resistant Gram-negative infections. Using mammalian kidney cell line, we demonstrated that polymyxin uptake into proximal tubular epithelial cells was saturable and occurred primarily through the apical membrane, suggesting involvement transporters in renal B. Megalin might play role accumulation cells.
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