Cardiac blood-pool scintigraphy in rats and hamsters: comparison of five radiopharmaceuticals and three pinhole collimator apertures.

摘要: Preclinical evaluation of cardiac drugs may require function in intact animals. To optimize the quality radionuclide measurements ventricular small animals, a comparison was made gated blood-pool scans recorded with five radiopharmaceuticals (99mTc-labeled human polyclonal IgG, 99mTc-human serum albumin labeled by two methods, and red blood cells radiolabeled 99mTc via vivo vitro methods) rats three pinhole apertures hamsters. The evaluated comparing count density ratios (LV/BACKGROUND LV/LIVER) ejection fractions each agent. edge definition left ventricle rate performance 1-, 2-, 3-mm In general, images obtained were superior to those proteins no significant differences between protein preparations detected. Left calculated all not significantly different. best 1-mm collimator. Ejection fraction acquisition time inversely related aperture size. A good compromise resolution sensitivity 2-mm