Rethinking Transcription Coupled DNA Repair

摘要: Nucleotide excision repair (NER) is an evolutionarily conserved, multistep process that can detect a wide variety of DNA lesions. Transcription coupled (TCR) subpathway NER repairs the transcribed strand faster than rest genome. RNA polymerase (RNAP) stalled at lesions mediates recruitment enzymes to damage site. In this review we focus on newly identified bacterial TCR pathway in which enzyme UvrD, conjunction with NusA, plays major role initiating process. We discuss tradeoff between new and conventional models TCR, how when each operates damage, necessity pervasive transcription maintaining genome integrity.