From Mfd to TRCF and Back Again-A Perspective on Bacterial Transcription-coupled Nucleotide Excision Repair.
作者： Alexandra M. Deaconescu , Margaret M. Suhanovsky
DOI: 10.1111/PHP.12661
关键词: Bacterial transcription 、 RNA polymerase 、 Computational biology 、 DNA 、 Nucleotide excision repair 、 Biology 、 Transcription (biology) 、 Crosstalk (biology) 、 T-cell receptor
摘要: Photochemical and other reactions on DNA cause damage corrupt genetic information. To counteract this damage, organisms have evolved intricate repair mechanisms that often crosstalk with DNA-based processes such as transcription. Intriguing observations in the late 1980s early 1990s led to discovery of transcription-coupled (TCR), a subpathway nucleotide excision repair. TCR, found all domains life, prioritizes for lesions located transcribed strand, directly read by RNA polymerase. Here, we give historical overview developments field bacterial starting from pioneering work Evelyn Witkin Aziz Sancar, which identification first transcription-repair coupling factor (the Mfd protein), recent studies uncovered alternative TCR pathways regulators.
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