Tissue specific response to DNA damage: C. elegans as role model.

摘要: The various symptoms associated with hereditary defects in the DNA damage response (DDR), which range from developmental and neurological abnormalities immunodeficiency to tissue-specific cancers accelerated aging, suggest that affects tissues differently. Mechanistic DDR studies are, however, mostly performed vitro, unicellular model systems or cultured cells, precluding a clear comprehensive view of multicellular organisms. Studies intact, animals models can vary according type, proliferation differentiation status cell. nematode Caenorhabditis elegans has become an important appears be especially well suited understand vivo responses as impact on development, reproduction health entire organism. C. germ cells are highly sensitive induction respond via classical, evolutionary conserved pathways aimed at efficient error-free maintenance genome. Somatic tissues, differently prioritize mechanisms promote growth function. In this mini-review, we describe differences have been uncovered utilizing role model.