DNA double-strand break repair in Caenorhabditis elegans
作者： Bennie B. L. G. Lemmens , Marcel Tijsterman
DOI: 10.1007/S00412-010-0296-3
关键词:
摘要: Faithful repair of DNA double-strand breaks (DSBs) is vital for animal development, as inappropriate can cause gross chromosomal alterations that result in cellular dysfunction, ultimately leading to cancer, or cell death. Correct processing DSBs not only essential maintaining genomic integrity, but also required developmental programs, such gametogenesis, which are deliberately generated. Accordingly, DSB deficiencies associated with various disorders including cancer predisposition and infertility. To avoid this threat, cells equipped an elaborate evolutionarily well-conserved network pathways. In recent years, Caenorhabditis elegans has become a successful model system study repair, important insights process during development. This review will discuss the major contributions progress C. field elucidate complex networks involved impact extends well beyond nematode phylum.
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