Chromosome Instability, Aging and Brain Diseases.

作者: Ivan Y. Iourov , Sergei I. Kutsev , Yuri B. Yurov , Svetlana G. Vorsanova

DOI: 10.3390/CELLS10051256

关键词:

摘要: Chromosome instability (CIN) has been repeatedly associated with aging and progeroid phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic …

参考文章(85)
Thomas Arendt, Martina K. Brückner, Andreas Lösche, Regional mosaic genomic heterogeneity in the elderly and in Alzheimer's disease as a correlate of neuronal vulnerability. Acta Neuropathologica. ,vol. 130, pp. 501- 510 ,(2015) , 10.1007/S00401-015-1465-5
Hans-Georg Fischer, Markus Morawski, Martina K. Brückner, Anja Mittag, Attila Tarnok, Thomas Arendt, Changes in neuronal DNA content variation in the human brain during aging Aging Cell. ,vol. 11, pp. 628- 633 ,(2012) , 10.1111/J.1474-9726.2012.00826.X
Giacomina Rossi, Donatella Conconi, Elena Panzeri, Serena Redaelli, Elena Piccoli, Laura Paoletta, Leda Dalprà, Fabrizio Tagliavini, Mutations in MAPT Gene Cause Chromosome Instability and Introduce Copy Number Variations Widely in the Genome Journal of Alzheimer's Disease. ,vol. 33, pp. 969- 982 ,(2013) , 10.3233/JAD-2012-121633
Antonio Currais, Tibor Hortobágyi, Salvador Soriano, The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease Aging (Albany NY). ,vol. 1, pp. 363- 371 ,(2009) , 10.18632/AGING.100045
Hei-man Chow, Karl Herrup, Genomic integrity and the ageing brain Nature Reviews Neuroscience. ,vol. 16, pp. 672- 684 ,(2015) , 10.1038/NRN4020
Scott R. Kennedy, Lawrence A. Loeb, Alan J. Herr, Somatic mutations in aging, cancer and neurodegeneration Mechanisms of Ageing and Development. ,vol. 133, pp. 118- 126 ,(2012) , 10.1016/J.MAD.2011.10.009
Ivan Y Iourov, Svetlana G Vorsanova, Yuri B Yurov, None, Single Cell Genomics of the Brain: Focus on Neuronal Diversity and Neuropsychiatric Diseases Current Genomics. ,vol. 13, pp. 477- 488 ,(2012) , 10.2174/138920212802510439
PATRICIA A. JACOBS, W. M. COURT BROWN, RICHARD DOLL, Distribution of Human Chromosome Counts in Relation to Age Nature. ,vol. 191, pp. 1178- 1180 ,(1961) , 10.1038/1911178A0
L.M. Russell, P. Strike, C.E. Browne, P.A. Jacobs, X chromosome loss and ageing. Cytogenetic and Genome Research. ,vol. 116, pp. 181- 185 ,(2007) , 10.1159/000098184
Jan Vijg, Somatic mutations, genome mosaicism, cancer and aging Current Opinion in Genetics & Development. ,vol. 26, pp. 141- 149 ,(2014) , 10.1016/J.GDE.2014.04.002