IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection.

摘要: Although mice from almost all inbred strains produce IgM anti-DNA antibody in response to B cell mitogens, only (NZB x NZW)F1 and other that are genetically predisposed autoimmunity spontaneously of the IgG isotype. Because display marked hyperactivity, production these has been thought result spontaneous, polyclonal activation. this may be true for antibodies, our results demonstrate antibodies not polyclonal. Rather, autoantibodies within an individual autoimmune mouse oligoclonal somatically mutated. These products clonally selective stimulation exhibit same characteristics as secondary immune conventional immunogens: they IgG, restricted,