Genistein Affects ERβ- But Not ERα-Dependent Gene Expression in the Hypothalamus

摘要: Isoflavone phytoestrogens are growing increasingly popular because of their reported cardiovascular and anticarcinogenic properties, but the effects these compounds in brain largely unknown. In a previous study, we found that an isoflavone supplement, containing mixture soy phytoestrogens, inhibited estrogen-dependent female sexual behavior was antiestrogenic for both ERα- ERβ-dependent gene expression hypothalamus. Here examined impact genistein, major component on rat brain. Genistein, at dietary concentration 100 or 500 ppm had no effect lordosis rats. However, genistein differential activity through ERα ERβ Genistein effect, either presence absence 17β-E2, oxytocin receptor density ventromedial nucleus hypothalamus, estrogen-dependen...