Influence of phytoestrogen diets on estradiol action in the rat uterus

摘要: The influence of coumestrol on the action estradiol was examined in oral and parenteral tests. Coumestrol did not antagonize uterotrophic when administered either prior to, or jointly with, E2 treatment, orally parenterally. Additive effects stimulation uterine weight reduction cytosolic estrogen receptor binding were observed following oral, but parenteral, administration coumestrol. On other hand, pretreatment appear to dampen estradiol's induction progestin receptors, protein, nuclear binding. However, even at those endpoints where action, itself produced an estrogenic response. These findings contradict assumption that all phytoestrogens are necessarily antiproliferative agents argue for specific identification actions each chemical.