Genetic predictors of depressive symptoms in cardiac patients.

作者: Jeanne M. McCaffery , Qing Ling Duan , Nancy Frasure-Smith , Amina Barhdadi , Francois Lespérance

DOI: 10.1002/AJMG.B.30824

关键词:

摘要: Numerous studies suggest that the prevalence of depression is greater among cardiac patients than in general population. However, little attention has been paid to possibility genetic contributions depressive symptoms patients. We conducted a candidate gene study focusing on genes related inflammation, platelet aggregation, endothelial function and omega-3 fatty acid metabolism as predictors 977 participants with established cardiovascular disease. Results suggested variation dysfunction predictive may be novel mechanism contributing

参考文章(42)
E Heyer, M Tremblay, Variability of the genetic contribution of Quebec population founders associated to some deleterious genes. American Journal of Human Genetics. ,vol. 56, pp. 970- 978 ,(1995)
Robert M Carney, Kenneth E Freedland, Gregory E Miller, Allan S Jaffe, Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanisms. Journal of Psychosomatic Research. ,vol. 53, pp. 897- 902 ,(2002) , 10.1016/S0022-3999(02)00311-2
Heather S Lett, James A Blumenthal, Michael A Babyak, Andrew Sherwood, Timothy Strauman, Clive Robins, Mark F Newman, Depression as a risk factor for coronary artery disease: evidence, mechanisms, and treatment. Psychosomatic Medicine. ,vol. 66, pp. 305- 315 ,(2004) , 10.1097/01.PSY.0000126207.43307.C0
Jeanne M. McCaffery, Nancy Frasure-Smith, Marie-Pierre Dubé, Pierre Théroux, Guy A. Rouleau, QingLing Duan, Francois Lespérance, Common genetic vulnerability to depressive symptoms and coronary artery disease: a review and development of candidate genes related to inflammation and serotonin. Psychosomatic Medicine. ,vol. 68, pp. 187- 200 ,(2006) , 10.1097/01.PSY.0000208630.79271.A0
Kazuomi Kario, Takefumi Matsuo, Hiroko Kobayashi, Reiko Asada, Miyako Matsuo, ‘Silent’ Cerebral Infarction Is Associated With Hypercoagulability, Endothelial Cell Damage, and High Lp(a) Levels in Elderly Japanese Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 16, pp. 734- 741 ,(1996) , 10.1161/01.ATV.16.6.734
Nancy Frasure-Smith, François Lespérance, Pierre Julien, Major depression is associated with lower omega-3 fatty acid levels in patients with recent acute coronary syndromes. Biological Psychiatry. ,vol. 55, pp. 891- 896 ,(2004) , 10.1016/J.BIOPSYCH.2004.01.021
B. Devlin, Kathryn Roeder, Genomic control for association studies. Biometrics. ,vol. 55, pp. 997- 1004 ,(1999) , 10.1111/J.0006-341X.1999.00997.X
George S Alexopoulos, Barnett S Meyers, Robert C Young, Scott Campbell, David Silbersweig, Mary Charlson, 'Vascular Depression' Hypothesis Archives of General Psychiatry. ,vol. 54, pp. 915- 922 ,(1997) , 10.1001/ARCHPSYC.1997.01830220033006
J.M. Wardlaw, P.A.G. Sandercock, M.S. Dennis, J. Starr, Is Breakdown of the Blood-Brain Barrier Responsible for Lacunar Stroke, Leukoaraiosis, and Dementia? Stroke. ,vol. 34, pp. 806- 812 ,(2003) , 10.1161/01.STR.0000058480.77236.B3