Mitogen activated protein kinasep38 pathway is an important component of the anti-inflammatory response in Mycobacterium avium subsp. paratuberculosis-infected bovine monocytes
作者： Cleverson D. Souza , Oral A. Evanson , Douglas J. Weiss
DOI: 10.1016/J.MICPATH.2006.04.002
关键词:
摘要: Abstract We investigated the role of cell signaling through mitogen-activated protein kinase-p38 (MAPK p38 ) pathway on antimicrobial functions and cytokine expression by bovine monocytes after ingestion Mycobacterium avium subsp. paratuberculosis . evaluated dynamic secretion interleukin (IL)-10, IL-12 tumor necrosis factor- α (TNF- as well phagosome acidification organism killing at several time points in vitro infection with M. Monocytes treated had a significant increase IL-10 2, 4, 6 h post-infection an TNF- 6, 24 h post-infection. In contrast, did not any point Moreover, MAPK was rapidly phosphorylated 10 60 min ingestion. Chemical inhibition (SB203580) resulted decreased increased Chemically blocking also phagosomes increasing capacity macrophages to kill organisms. Taken together, these results indicated that selective activation may be major mechanism exploited circumvent antimycobacterial effects mononuclear phagocytes.
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