Role of mitogen-activated protein kinase pathways in the production of tumor necrosis factor-alpha, interleukin-10, and monocyte chemotactic protein-1 by Mycobacterium tuberculosis H37Rv-infected human monocytes.
作者： Chang-Hwa Song
关键词:
摘要: The role of mitogen-activated protein kinase (MAPK) pathways in the secretion tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, IL-8, and monocyte chemotactic protein-1 (MCP-1) was investigated human monocytes that were infected with Mycobacterium tuberculosis H37Rv. Analysis extracellular signal-regulated kinases 1 2 (ERK1/2) p38 showed rapid phosphorylation both subfamilies response to M. Using highly specific inhibitors (SB203580) MAPK kinase-1 (U0126 PD98059), we found ERK essential for H37Rv-induced TNF-alpha production, whereas activation pathway, but not ERK, IL-10 production. Interestingly, p38, critical MCP-1 from However, IL-8 regulated by ERK1/2 or MAPK. Collectively, these results suggest induction pathway is required expression TNF-alpha, IL-10, during H37Rv infection.
springer.com
sci-hub.se 参考文章(34)
Hubert M. Tse, Steven I. Josephy, Edward D. Chan, Darren Fouts, Andrea M. Cooper, Activation of the Mitogen-Activated Protein Kinase Signaling Pathway Is Instrumental in Determining the Ability of Mycobacterium avium to Grow in Murine Macrophages Journal of Immunology. ,vol. 168, pp. 825- 833 ,(2002) , 10.4049/JIMMUNOL.168.2.825
K. Murali Krishna Rao, MAP kinase activation in macrophages. Journal of Leukocyte Biology. ,vol. 69, pp. 3- 10 ,(2001) , 10.1189/JLB.69.1.3
Norbert Reiling, Antje Blumenthal, Hans-Dieter Flad, Martin Ernst, Stefan Ehlers, Mycobacteria-Induced TNF-α and IL-10 Formation by Human Macrophages Is Differentially Regulated at the Level of Mitogen-Activated Protein Kinase Activity The Journal of Immunology. ,vol. 167, pp. 3339- 3345 ,(2001) , 10.4049/JIMMUNOL.167.6.3339
YuanGuang Lin, JianHua Gong, Ming Zhang, Wanfen Xue, Peter F. Barnes, Production of Monocyte Chemoattractant Protein 1 in Tuberculosis Patients Infection and Immunity. ,vol. 66, pp. 2319- 2322 ,(1998) , 10.1128/IAI.66.5.2319-2322.1998
C O Zachariae, A O Anderson, H L Thompson, E Appella, A Mantovani, J J Oppenheim, K Matsushima, Properties of monocyte chemotactic and activating factor (MCAF) purified from a human fibrosarcoma cell line. Journal of Experimental Medicine. ,vol. 171, pp. 2177- 2182 ,(1990) , 10.1084/JEM.171.6.2177
Zong-Mei Bian, Susan G Elner, Ayako Yoshida, Steven L Kunkel, Jia Su, Victor M Elner, Activation of p38, ERK1/2 and NIK Pathways is Required for IL-1β and TNF-α-induced Chemokine Expression in Human Retinal Pigment Epithelial Cells Experimental Eye Research. ,vol. 73, pp. 111- 121 ,(2001) , 10.1006/EXER.2001.1019
Lufen Chang, Michael Karin, Mammalian MAP kinase signalling cascades Nature. ,vol. 410, pp. 37- 40 ,(2001) , 10.1038/35065000
Ian M Orme, Andrea M Cooper, Cytokine/chemokine cascades in immunity to tuberculosis. Immunology Today. ,vol. 20, pp. 307- 312 ,(1999) , 10.1016/S0167-5699(98)01438-8
Asima Bhattacharyya, Shresh Pathak, Manikuntala Kundu, Joyoti Basu, Mitogen-activated protein kinases regulate Mycobacterium avium-induced tumor necrosis factor-α release from macrophages Fems Immunology and Medical Microbiology. ,vol. 34, pp. 73- 80 ,(2002) , 10.1111/J.1574-695X.2002.TB00605.X
Anna M Fietta, Monica Morosini, Federica Meloni, Alessia Marone Bianco, Ernesto Pozzi, PHARMACOLOGICAL ANALYSIS OF SIGNAL TRANSDUCTION PATHWAYS REQUIRED FOR MYCOBACTERIUM TUBERCULOSIS -INDUCED IL-8 AND MCP-1 PRODUCTION IN HUMAN PERIPHERAL MONOCYTES Cytokine. ,vol. 19, pp. 242- 249 ,(2002) , 10.1006/CYTO.2002.1968