Polysaccharide extracted from Sargassum fulvellum leads to macrophage activation and Th1 polarization in splenocytes
作者： Nak-Yun Sung , Hye-Min Kim , Eui-Baek Byun , Jae-Nam Park , Chulhwan Park
DOI: 10.1007/S12562-015-0886-3
关键词:
摘要: Marine organisms are a rich source of structurally diverse bioactive compounds that play vital role in human health and nutrition. This study examined the immunomodulatory activities polysaccharide extracted from Sargassum fulvellum RAW264.7 macrophages mice splenocytes. S. extract (SPE) was obtained by ethanol precipitation after hot water extraction for 2 h. SPE treatment macrophage cells did not induce cytotoxicity, but increased levels nitric oxide (NO) cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-6, IL-12p70), except IL-10, mediate immune suppression. Treatment also significantly surface activation markers CD80 CD86. Additionally, modulated mitogen-activated protein kinases (MAPKs) nuclear (NF)-κB signaling. In splenocytes, markedly cell proliferation Th1 (interferon [IFN]-γ), increase Th2 (IL-4). Taken together, these results suggest could potentially be used as an agent.
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