Suppression of spontaneous reticulum cell sarcoma development and of syngeneic stimulator cell by anti-mu treatment of SJL/J mice.

摘要: The cellular origin of reticulum cell sarcoma (RCS) in SJL/J mice was studied by comparing the incidence spontaneous RCS control and suppressed with goat anti-mu Ig from birth on. At 10 months age had 0% as opposed to 60% mice. Growth two i.v. injected transplantable lines approximately compared growth normal Proliferative responses thymus lymph node cells RCS, mitomycin-treated syngeneic spleen (M. Spl.) Con A, PHA were entirely normal. However, M. Spl. caused minimal or no stimulation T responders. results suggest that stimulator is B origin, either representing a direct precursor indirectly influencing appearance. A is, furthermore, agreement some its characteristics, such surface markers (Ia antigens, Ly b) vivo localization properties.