摘要: The multicatalytic proteinase complex (proteasome) is a highmolecular-mass (approximately 700 kDa) intracellular which has been isolated under variety of different names from wide eukaryotic cells and tissues (reviewed, Rivett, 1989a; Orlowski, 1990). composed at least 24 subunits include many polypeptides arranged in cylindrical structure. Other multi-subunit complexes with structures 'prosomes', that are widely distributed 19 S ribonucleoprotein particles were thought to be involved the control translation (Schmid et al., 1984; Martins de Sa 1986), erythrocyte cylindrin (Harris, 1988), number other partially characterized 16-22 particles. 'Prosomes' certain related have shown proteolytic activity share antigenic cross-reactivity (Falkenburg 1988) therefore believed same. most often referred either as (Dahlmann 1988; Orlowski Wilk, or, more recently, proteasomes (Arrigo their properties broadly similar irrespective
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