Ethnic Differences in Pharmacogenetically Relevant Genes

摘要: There is great heterogeneity in the way humans respond to medications, often requiring empirical strategies define appropriate drug therapy for each patient. Genetic polymorphisms metabolizing enzymes, transporters, receptors, and other targets provide putative markers predicting which patients will experience extreme toxicity treatment failure. Both quantitative (allele frequency) qualitative (specific allele) differences polymorphic genes have been observed between different population groups. For example, frequency of mutations thiopurine methyltransferase lower Chinese than Caucasian populations. In addition, predominant mutation responsible deficient enzyme activity differs two populations (TPMT*l3C versus TPMT*3A). Understanding influence ethnicity on pharmacogenomics allow comprehensive using genome optimize throughout world.