Nicotine Metabolism in Young Adult Daily Menthol and Nonmenthol Smokers

摘要: Introduction Menthol cigarette smoking may increase the risk for tobacco smoke exposure and inhibit nicotine metabolism in liver. Nicotine is primarily mediated by enzyme CYP2A6 metabolite ratio (NMR = trans 3' hydroxycotinine/cotinine) a phenotypic proxy activity. No studies have examined differences this biomarker among young adult daily menthol nonmenthol smokers. This study compares biomarkers of Methods Saliva cotinine carbon monoxide were measured multiethnic sample smokers aged 18-35 (n 186). Nicotine, cotinine, cotinine/cigarette per day ratio, hydroxycotinine, NMR, expired compared. Results The geometric means nicotine, did not significantly differ between NMR was lower compared with after adjusting race/ethnicity, gender, body mass index, smoked (0.19 vs. 0.24, P .03). White had higher cotinine/cigarettes than white adjusted model. unadjusted model (0.24 0.31, .05) remained marginally significant (0.28 0.34, .06). We observe these Native Hawaiians Filipinos. Conclusions Young slower rates Studies are needed to determine utility cessation treatment assignments.