Evaluation of total intravenous anesthesia with propofol-guaifenesin-medetomidine and alfaxalone-guaifenesin-medetomidine in Thoroughbred horses undergoing castration.

摘要: Anesthetic and cardiorespiratory effects of total intravenous anesthesia (TIVA) technique using propofol-guaifenesin-medetomidine (PGM) alfaxalone-guaifenesin-medetomidine (AGM) were preliminarily evaluated in Thoroughbred horses undergoing castration. Twelve male assigned randomly into two groups. After premedication with (IV) administrations medetomidine (5.0 µg/kg) butorphanol (0.02 mg/kg), was induced guaifenesin (10 mg/kg IV), followed by either propofol (2.0 IV) (group PGM: n=6) or alfaxalone (1.0 AGM: n=6). Surgical maintained for 60 min at a constant infusion (3.0 mg/kg/hr) PGM) (1.5 AGM), combination (80 µg/kg/hr). Responses to surgical stimuli, values, induction recovery characteristics recorded throughout anesthesia. During induction, one horse paddled group PGM. All from AGM adequate anesthetic depth In PGM, 3 showed increased cremaster muscle tension slight movement requiring additional IV maintain No exhibited apnea, although arterial oxygen decreased less than mmHg. Recovery quality good excellent both conclusion, TIVA PGM available horses. techniques provided clinically acceptable general mild depression. However, inspired air should be supplemented prevent hypoxemia during